{"id":6566,"date":"2023-10-25T04:29:41","date_gmt":"2023-10-25T04:29:41","guid":{"rendered":"https:\/\/iptechinsider.com\/?p=6566"},"modified":"2023-10-25T04:29:45","modified_gmt":"2023-10-25T04:29:45","slug":"car-t-cell-therapy-for-cancer-treatment","status":"publish","type":"post","link":"https:\/\/iptechinsider.com\/car-t-cell-therapy-for-cancer-treatment\/","title":{"rendered":"CAR-T CELL THERAPY FOR CANCER TREATMENT \u2013 A DEEPER LOOK"},"content":{"rendered":"\t\t
Cancer is a condition in which cells undergo unrestricted growth due to variations in DNA. Cancer is one of the diseases that can affect any part of the body. There is a wide range of factors that could lead to cancer development such as lifestyle, food, medications, infections, chemicals, heredity, hormones, etc. Next comes the question of whether any treatment is available with a complete cure. Extensively studied and FDA-approved therapies are available for various types of cancer.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t Some of the well-known therapies for the treatment of cancer are:<\/p> Immunotherapy treatments are those that help strengthen the immune system and combat cancer. Immunotherapy based cancer treatments have proven effective against various malignant cancers, such as breast, cervical, head, kidney, and neck cancers, B-cell lymphoma, Hodgkin lymphoma, non-Hodgkin lymphoma, melanoma, multiple myeloma, and more. Monoclonal antibodies, such as rituximab, cetuximab, and nivolumab, are used to activate the immune system and treat these cancers. Another emerging immunotherapy treatment is cell therapy, in which infected cells can be replaced with healthy ones.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy treatment that uses a patient’s genetically modified T-cells for the recognition and attack of cancer cells. CAR T-cell therapy is more effective against certain types of cancers, such as B-cell leukemia, and a response rate of 50% was observed in patients with relapsed (cancer recurrence after initial treatment) or refractory (lack of response to other treatments) diffuse large B-cell lymphoma. There are still challenges to overcome in the development and implementation of CAR T-cell therapy, such as cytokine release syndrome (CRS), which is a side effect of immunotherapy treatment where a large amount of cytokine proteins are released, leading to inflammation in the body. Additionally, neurotoxicity can occur, which can affect the function of the nervous system. Resolving these side effects requires personalized therapies.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t Chimeric antigen receptor (CAR) T-cell therapy involves targeting specific tumor markers, such as CD19, MUC16, MUC1, CA1X, CEA, CD8, CD7, CD10, CD20, CD22, etc., to identify cancerous cells. CAR- T cell therapy is known for its process, which includes isolating T cells (a type of white blood cell) from the patient, genetically modifying the cells, multiplying them, and transferring them back to the patient, where they attack cancer cells. In the case of allogeneic cell therapy, T cells from a donor are used. Many companies and university research and development departments are working towards developing cancer therapies. Recently, the FDA approved the following CAR-T cell therapies:<\/p> After the approval of CAR-T cell therapy by the FDA, approximately 65 companies are involved in CAR-T cell therapies for various types of cancer treatment. Thirty-five percent of the companies are in the prototype stage of CAR-T cell development for cancers targeting antigens.<\/p> Key players in the market who deals with CART-cell production and involved in CART-cell therapies are NOVARTIS, GILEAD SCIENCES, JOHNSON & JOHNSON, GENSCRIPT BIOTEC CORPORATION, PROMAB BIOTECHNOLOGIES, BIO4T2, ORICELL THERAPEUTICS, CARSGEN THERAPEUTICS, ALLOGENE THERAPEUTICS, BRISTOL-MYERS SQUIBB CO, ELPIS BIOPHARMACEUTICALS, KIROMIC BIOPHARMA, T MAXIMUM BIOTECH, AUTOLUS THERAPEUTICS, CELLECTIS, CHONGQING PRECISION BIOTECH, CTG PHARMA, ELICERA THERAPEUTICS, KAEDI BIOTHERAPEUTICS, and MUSTANG BIO.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t Research related to CAR-T cell therapy started in the early 1990s, but research on CART-cell therapy for cancer treatment became extensive after 2014.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t First developed and approved CAR T cell-based therapy was tisagenlecleucel (Kymriah) in 2017 for cancer patients until the age of 25. Since then, there has been significant research on CAR T cell therapy for various types of cancer.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t \n No Data Found <\/p>\n <\/div>\n <\/div>\n Well-known types of cancer therapies used across the world as treatments<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
Recent advancements in cancer therapy - Immunotherapy<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
CAR -T Cell Therapy<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
Manufacturing of CAR-T cell<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
What is the Intellectual Property factor in CAR-T cell therapy?<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
What has been the trend of innovation based on studies related to CART-cell therapy?<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
Patent innovation trend on CAR-T cell therapy<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
Where all the patents are filed globally for CAR-T cell therapy?<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n Market coverage <\/h4>\n <\/div>\n